Regenica

Regenica® with MRelex™ next generation growth factor technology is designed to stimulate your skin’s natural repair and renewal mechanisms.

General Questions:

What is the Regenica® skin care system?

Regenica® is a skin care system made with the power and promise of regenerative science. The MRCx™ next generation growth factor technology is formulated to enhance skin’s natural repair and renewal and help prevent the signs of aging.

What is MRCx™?

MRCx™ is next generation growth factor technology made by a proprietary and patented process. It is a rejuvenating blend of physiologically balanced growth factors that are naturally secreted by skin cells. These cells have been conditioned to act like younger cells resulting in younger, fresher growth factors

What are growth factors?

Growth factors are natural proteins in your body that support the skin’s natural signaling properties, which can decline with age.

What products make up the Regenica® skin care system?

  • Regenica® Renew SPF 15 helps protect skin from harmful UV rays. It’s the only UV protectant formulated with MRCx™ next generation growth factor technology to enhance skin’s natural repair and renewal and help prevent the signs of aging
  • Regenica® Replenishing Crème hydrates skin and helps reverse the signs of aging. The combination of MRCx™ next generation growth factor technology, powerful peptides, and advanced moisturizers replenishes what you lose over time. Nourish your skin and reveal your most radiant complexion.
  • Regenica® Repair Complex helps enhance skin renewal. Made with MRCx™ next generation growth factor technology, it’s specifically formulated for sensitive skin.
  • Regenica® Revitalizing Eye Crème—Regenica® Revitalizing Eye Crème is specifically formulated for the delicate skin around the eye. It’s a revolutionary formulation of MRCx™ next generation growth factor technology with advanced peptides, powerful antioxidants, and superior moisturizing agents. Regenica® Revitalizing Eye Crème quickly softens the look of fine lines and wrinkles while reducing the appearance of puffiness and dark under-eye circles.
  • Regenica® Recovery Gel—Regenica® Recovery Gel is a soothing balm that helps quickly heal skin. It infuses MRCx™ next generation growth factor technology with the most trusted natural anti-inflammatory and calming agents, including arnica, vitamin K, aloe vera, beta-glucan, and SymCalmin™. Help reverse the signs that your skin was ever less than perfect.

Why is the Regenica® formula unique?

Only Regenica® with MRCx™ next generation growth factor technology was specifically developed to enhance skin’s natural repair and renewal and help prevent the signs of aging. Dr.

Gail Naughton, who originally helped develop TNS (Tissue Nutrient System from SkinMedica) continued her research for over a decade before discovering MRCx™. She found a way to nourish delicate skin cells without the use of bovine serum, allowing them to revert back to a younger stage and exhibit stem cell properties. The result is younger, fresher cells that make younger, fresher growth factors.

How long has Regenica® been on the market?

After years of advanced research and development, Regenica® was launched by its original scientific founder, Dr. Gail Naughton, in 2009. In 2012, Regenica® became exclusively available through Suneva Medical.

Where and how is Regenica® available for purchase?

Regenica® is available only through physicians’ practices. Consumers can visit Regenica.com to find a physician. Physicians are encouraged to visit Regenica.com to learn how to bring Regenica® into their office.

What is the suggested MSRP?

The suggested MSRP for Regenica® Renew SPF 15 or Regenica® Replenishing Crème is $175.00 each. The Repair Complex is $150. The suggested MSRP for Regenica® Revitalizing Eye Crème is

$92. The suggested MSRP for Regenica® Recovery Gel is $30.

How is Regenica with MRCx different from SkinMedica’s TNS product? From other growth factor products?

Only Regenica® with MRCx™ next generation growth factor technology was specifically developed to enhance skin’s natural repair and renewal and help prevent the signs of aging. Dr. Gail Naughton, who originally helped develop TNS, continued her research for over a decade before discovering MRCx™. She found a way to nourish delicate skin cells without the use of bovine serum, allowing them to revert back to a younger stage and exhibit stem cell properties. The result is younger, fresher cells that make younger, fresher growth factors.

Regenica® was developed using the latest technological and scientific methods. While conventional culturing techniques use atmospheric oxygen levels of 21%, Regenica® creates an embryonic-like environment by reducing oxygen levels to less than 5%, anchoring the cells on dextran microbeads and maintaining the cells in suspension with constant, gentle motion. This process allows the cells to revert back to an earlier stage and exhibit stem cell properties, causing the cells to release multipotent growth factors, unlike any other growth factor product.

Physician-Focused:

Who makes and sells Regenica®?

Regenica® was developed by Dr. Gail Naughton at Histogen, Inc. and licensed to Suneva Medical for distribution in 2012.

What does Regenica® do?

Regenica® with MRCx™ next generation growth factor technology enhances skin’s own natural capacity to repair and renew Itself. Clinical studies prove that when used consistently, Regenica®

improves the appearance of fine lines and wrinkles, reduces the appearance of pores, and evens out skin tone appearance to reveal a more radiant complexion. *

* Suneva Medical data on file

Why should physicians and my readers be interested in Regenica?

Whether patients are devoted to a particular ingredient or product, growth factors are an important part of a balanced skin care regimen. Naturally occurring growth factors support the skin’s natural signaling properties, which can decline with age. Only Regenica® has MRCx™ next generation growth factor technology which may enhance repair, renewal, and help reverse the signs of aging. Backed by sound science, and clinical data, the Regenica® system can give a physician’s practice a clear edge.

What kind of research has been done to determine efficacy? *

Regenica® is backed by clinical data. The Regenica® system was shown to be safe in four separate clinical studies.

Two trials studied the effects of Regenica® after laser treatments and were published in peer- reviewed journals. They showed that Regenica® enhanced healing after a laser procedure.

Two anti-aging studies showed that using Regenica® resulted in smoother skin texture and tone as well as a reduction in the appearance of fine lines and wrinkles.

In addition, a consumer preference survey (the “Growth Factor Challenge”) demonstrated that consumers preferred the effects and aesthetics of Regenica® over TNS Essential Serum®.

*Suneva Medical data on file.

What are some of the most prominent results patients reported?

In a single-blind study evaluating 14 subjects who used Regenica® Renew SPF 15 (formerly Day Repair SPF 15) and Replenishing Crème (formerly Overnight Repair), 90% saw a reduction in pore size, 82% noted improved skin texture, and 64% noted more radiant skin.*

Another single-blind study evaluated 18 subjects who used Regenica® Renew SPF 15 (formerly Day Repair) and Replenishing Crème (formerly Overnight Repair). The investigator noted statistically significant improvements in the appearance of skin tone, texture, wrinkles, radiance, translucency, and blotchiness. 100% of subjects were satisfied and would recommend Regenica® to a friend.*

*Suneva Medical data on file.

Is it safe? How has that been proven?

Regenica® is backed by sound science and clinical data. The Regenica® skin care line was shown to be safe in four separate clinical studies. In addition, MRCx™ underwent a full battery of pre- clinical testing and showed no signs of toxicity. Additional testing of MRCx™ demonstrated no irritation in skin and ocular studies, and no allergenicity. In addition, each product undergoes extensive clinical testing.

What are the side effects?

In clinical studies, there were no treatment-related adverse events (e.g. irritant or allergic dermatitis) reported. As with any skin care product, some patients may experience irritation, redness and sensitivity.

I thought growth factors were too large to penetrate the skin?

The Regenica® system of products is designed to be quickly absorbed by the skin. The proof is in the clinical results. Growth factors are large molecules, but they can reach the stratum corneum of the epidermis through follicles where the skin is thinner and through sweat glands.

Consumer-Focused:

How does Regenica® work?

Regenica® with MRCx™ next generation growth factor technology enhances your skin’s own natural capacity to repair and renew itself. Clinical studies prove that when used consistently, Regenica® improves the appearance of fine lines and wrinkles, reduces the appearance of pores, and evens out skin tone appearance to reveal a more radiant complexion.*

*Suneva Medical data on file

What’s in Regenica®?

Only Regenica® has MRCx™ growth factor technology, specifically developed to support repair, renewal, and help reverse the signs of aging. Used alone or in combination with other products, it’s part of a balanced skin care regimen to restore optimal skin health.

What is MRCx™?

MRCx™ is next generation growth factor technology made by a proprietary, patented process. It is a rejuvenating blend of physiologically balanced growth factors that are naturally secreted by skin cells. These cells have been conditioned to act like younger cells resulting in younger, fresher growth factors.

What is a growth factor and is it safe?

Growth factors are naturally occurring proteins in your body that may signal and simulate skin repair, regeneration, and the production of the collagen and elastin that makes your skin soft and supple. Over time, natural levels of growth factors decline. Supplementing skin with growth factors may help return skin to its optimal health.

The growth factors in Regenica® MRCx™ next generation growth factor technology supplement the growth factors that naturally occur in skin. Clinical studies have shown MRCx™ to be safe*. For more details on any skin care regimen’s safety, its best to speak with your doctor or skin care specialist.

*Suneva Medical data on file.

Why should consumers and my readers be interested in Regenica®?

Whether you love a particular ingredient or product, growth factors are a key part of a balanced skin care regimen. Growth factors supplement the skin’s natural anti-aging properties, which decline with age, to maintain a youthful and radiant complexion. Only Regenica® has MRCx™ next generation growth factor technology specifically developed to support repair, renewal,, and help reverse the signs of aging. It’s backed by sound science, and clinical data.*

*Suneva Medical data on file.

Must I undergo laser treatment to get results from Regenica®?

No. The Regenica® Repair Complex was created to help speed the laser treatment recovery process, but it can also be effectively integrated into a regular skin care regimen, especially for sensitive skin.

What kind of results can I expect? How long does it take to see results?

Patients may see marked improvement in skin hydration after first use. In an anti-aging clinical study, subjects using Regenica® Renew SPF 15 and Replenishing Crème saw significant anti-aging results in as little as two weeks. In a post laser study, subjects using Regenica® Repair Complex had improved healing in as little as three to five days. But the best results are seen with continued use.*

It’s recommended that patients make an appointment with a dermatologist or skin care specialist to develop a personalized skin care regimen that will be safe and effective for their unique skin.

*Suneva Medical data on file.

Can I use just the Renew SPF 15 or just the Replenishing Crème? Or do they need to be used together?

Regenica® Renew SPF 15 and Replenishing Crème can be used individually, but the clinical studies evaluated results when used together. Both products contain MRCx™ to deliver a twice daily dose of growth factors.

It’s recommended that patients make an appointment with a dermatologist or skin care specialist to develop a personalized skin care regimen that will be safe and effective for their unique case.

What does physician-dispensed mean?

Physician-dispensed means you can’t purchase the product at a department store or at a drug store. Physician-dispensed products are available at dermatology, plastic surgery and other physician practices.

Backed by the latest science, physician-dispensed products are an excellent option for patients looking to go beyond the department store counter for truly effective skin care regimens.

Which doctors offer the product?

Visit www.regenica.com to find a physician near you.

Are there negative side effects of Regenica®?

Clinical studies showed no subjects experienced negative side effects related to use of Regenica®*. However, as with any skin care product, some users may experience irritation, redness, and sensitivity. To learn about the side effects associated with any skin care treatment and what patients may need to watch out for, patients should make an appointment with their doctor or skin care specialist.

*Suneva Medical data on file.

How do I receive a sample?

During a consultation with a physician, it’s suggested that patients inquire about Regenica®. Their physician may demonstrate the product and how it works.

For media: Suneva has samples available for media. Please contact suneva@formulapr.com to request a sample.

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